Title : Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.

Pub. Date : 2018 Mar 1

PMID : 30108944






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The introduction of a 4-fluorophenyl substituent resulted in retained high COX-2 affinity, making these compounds together with the feasible one step reaction promising candidates for the development of fluorine-18 labelled radiotracers. Fluorine-18 mitochondrially encoded cytochrome c oxidase II Homo sapiens