Pub. Date : 2018 Oct
PMID : 30106452
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Platinum increased p53 and p-p53 (ser15) in a time-dependent manner in 3D cultures. | Platinum | tumor protein p53 | Homo sapiens |
| 2 | Platinum increased p53 and p-p53 (ser15) in a time-dependent manner in 3D cultures. | Platinum | tumor protein p53 | Homo sapiens |
| 3 | Under 3D culture condition, knockdown of integrin beta4 did not detectably change the basal p53 protein level but increased p53 and p-p53 (ser15) protein accumulation induced by platinum. | Platinum | tumor protein p53 | Homo sapiens |
| 4 | Under 3D culture condition, knockdown of integrin beta4 did not detectably change the basal p53 protein level but increased p53 and p-p53 (ser15) protein accumulation induced by platinum. | Platinum | tumor protein p53 | Homo sapiens |
| 5 | Knockdown of wild-type p53 decreased sensitivity to platinum in 3D cultures. | Platinum | tumor protein p53 | Homo sapiens |
| 6 | Since it has been proven that platinum damages DNA to kill cells and p53 plays a key role in the DNA damage response, our results indicated that integrin beta4 reduced DNA damage-induced p53 activation to decrease chemosensitivity in CRC. | Platinum | tumor protein p53 | Homo sapiens |