Pub. Date : 2019 Feb
PMID : 30102427
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Buprenorphine/samidorphan combination (BUP/SAM) is an opioid system modulator being investigated as adjunctive treatment for major depressive disorder. | Buprenorphine | COMM domain containing 3 | Homo sapiens |
| 2 | BUP/SAM is a fixed-dose combination of buprenorphine, a partial mu-opioid receptor agonist and kappa-opioid receptor antagonist, and samidorphan, a mu-opioid receptor antagonist added to address the abuse and dependence potential of buprenorphine. | Buprenorphine | COMM domain containing 3 | Homo sapiens |
| 3 | BUP/SAM is a fixed-dose combination of buprenorphine, a partial mu-opioid receptor agonist and kappa-opioid receptor antagonist, and samidorphan, a mu-opioid receptor antagonist added to address the abuse and dependence potential of buprenorphine. | Buprenorphine | COMM domain containing 3 | Homo sapiens |
| 4 | In this study, we assessed the effect of samidorphan on the abuse potential of buprenorphine in the BUP/SAM combination in nondependent, recreational, adult opioid users (ClinicalTrials.gov ID: NCT02413281). | Buprenorphine | COMM domain containing 3 | Homo sapiens |
| 5 | These findings indicate that samidorphan substantially reduces the abuse potential of buprenorphine in the BUP/SAM combination. | Buprenorphine | COMM domain containing 3 | Homo sapiens |