Title : Upregulation of C/EBPβ and TSC2 by an HDAC inhibitor CG200745 protects heart from DOCA-induced hypertrophy.

Pub. Date : 2019 Mar

PMID : 30099761






3 Functional Relationships(s)
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1 We hypothesized that an HDAC inhibitor, CG200745 (CG), ameliorates cardiac hypertrophy through the inhibition of mTORC1 signaling by upregulating of the CCAAT/enhancer-binding protein-beta (C/EBP-beta)/TSC2 pathway. N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide CREB regulated transcription coactivator 1 Mus musculus
2 We hypothesized that an HDAC inhibitor, CG200745 (CG), ameliorates cardiac hypertrophy through the inhibition of mTORC1 signaling by upregulating of the CCAAT/enhancer-binding protein-beta (C/EBP-beta)/TSC2 pathway. N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide CREB regulated transcription coactivator 1 Mus musculus
3 Thus, CG ameliorates cardiac hypertrophy through the inhibition of mTORC1 signaling via upregulation of the C/EBP-beta/TSC2 pathway in DOCA-induced hypertensive rats. N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide CREB regulated transcription coactivator 1 Mus musculus