Title : Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.

Pub. Date : 2018 Dec

PMID : 30099074






1 Functional Relationships(s)
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1 CONCLUSIONS: In mice, we demonstrated that combined inactivation of Mir34a and Tp53 promotes azoxymethane-induced colorectal carcinogenesis and tumor progression and metastasis by increasing levels of IL6R and PAI1. Azoxymethane interleukin 6 receptor, alpha Mus musculus