Title : Decarbamoylation of acetylcholinesterases is markedly slowed as carbamoyl groups increase in size.

Pub. Date : 2018 Oct 1

PMID : 30098983






7 Functional Relationships(s)
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Protein Name
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1 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates acetylcholinesterase (Cartwright blood group) Homo sapiens
4 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates acetylcholinesterase (Cartwright blood group) Homo sapiens
5 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates acetylcholinesterase (Cartwright blood group) Homo sapiens
6 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates acetylcholinesterase (Cartwright blood group) Homo sapiens
7 Therefore, carbamates are effective AChE inhibitors that have been developed as insecticides and as therapeutic agents. Carbamates acetylcholinesterase (Cartwright blood group) Homo sapiens