Pub. Date : 2018 Jul 15
PMID : 30097127
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Investigation of ovatodiolide, a macrocyclic diterpenoid, as a potential inhibitor of oral cancer stem-like cells properties via the inhibition of the JAK2/STAT3/JARID1B signal circuit. | ovatodiolide | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Furthermore, Ova-mediated anti-cancer effects were associated with the dose-dependent reduction in the expression levels of STAT3, p-STAT3, pJAK2, pAKT and pERK1/2 protein. | ovatodiolide | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | Furthermore, Ova-mediated anti-cancer effects were associated with the dose-dependent reduction in the expression levels of STAT3, p-STAT3, pJAK2, pAKT and pERK1/2 protein. | ovatodiolide | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | CONCLUSION: These results demonstrate that Ova effectively suppressed oral tumorigenesis and stemness properties via JAK2/STAT3 signaling. | ovatodiolide | signal transducer and activator of transcription 3 | Mus musculus |