Pub. Date : 2017 Jul 1
PMID : 30090509
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in Caenorhabditis elegans. | Endosulfan | Mitogen-activated protein kinase 15 | Caenorhabditis elegans |
| 2 | However, the apoptosis in the loss-of-function strains of JNK and p38 MAPK signaling pathways was completely or mildly suppressed under endosulfan stress. | Endosulfan | Mitogen-activated protein kinase 15 | Caenorhabditis elegans |
| 3 | The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell apoptosis. | Endosulfan | Mitogen-activated protein kinase 15 | Caenorhabditis elegans |
| 4 | The apoptotic effects of endosulfan were blocked in the mutants of jnk-1/JNK-MAPK, sek-1/MAP2K, and pmk-1/p38-MAPK, suggesting that these downstream genes play an essential role in endosulfan-induced germ cell apoptosis. | Endosulfan | Mitogen-activated protein kinase 15 | Caenorhabditis elegans |
| 5 | Our data provide evidence that endosulfan increases germ cell apoptosis, which is regulated by mitochondrial function, JNK and p38 MAPK cascades. | Endosulfan | Mitogen-activated protein kinase 15 | Caenorhabditis elegans |