Pub. Date : 2016 Jan 1
PMID : 30090338
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through beta-catenin signaling pathway. | Diethylnitrosamine | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 2 | We found that both the mRNA and protein expression levels of beta-catenin were aberrant in all liver tissues, accompanied by inflammation, steatosis, fibrosis and hepatic neoplasm after 10-week exposure of diethylnitrosamine (dissolved in sesame oil, 0.16 mmol per kg body weight) to mice. | Diethylnitrosamine | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 3 | Altogether, our results show that long-term diethylnitrosamine exposure at trace amounts and low frequency can also induce hepatotoxicity (including inflammation, steatosis and fibrosis) and consequently aberrant activation of beta-catenin which in turn plays an important role in the initiation and promotion of liver tumors. | Diethylnitrosamine | catenin (cadherin associated protein), beta 1 | Mus musculus |