Title : Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC).

Pub. Date : 2018 Sep 14

PMID : 30089652






1 Functional Relationships(s)
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1 We observed that the decrease in AR may occur through simvastatin-mediated inhibition of the mTOR pathway, whose activation was associated with increased HMGCR and AR expression. Simvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens