Pub. Date : 2018 Sep 15
PMID : 30086290
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we hypothesized that PPAR-beta/delta agonist GW0742 can activate miR-17-5p, consequently inhibiting TXNIP and ASK1/p38 pathway leading to attenuation of apoptosis. | GW0742 | thioredoxin interacting protein | Rattus norvegicus |
| 2 | Furthermore, GW0742 treatment increased PPAR-beta/delta nuclear expression and miR-17-5p level and reduced TXNIP in ipsilateral hemisphere after HI, resulting in inhibition of ASK1/p38 pathway and attenuation of apoptosis. | GW0742 | thioredoxin interacting protein | Rattus norvegicus |
| 3 | For the first time, we provide evidence that intranasal administration of PPAR-beta/delta agonist GW0742 attenuated neuronal apoptosis at least in part via PPAR-beta/delta/miR-17/TXNIP pathway. | GW0742 | thioredoxin interacting protein | Rattus norvegicus |