Title : Quantitative characterization of UDP-glucuronosyltransferase 2B17 in human liver and intestine and its role in testosterone first-pass metabolism.

Pub. Date : 2018 Oct

PMID : 30086285






3 Functional Relationships(s)
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1 Quantitative characterization of UDP-glucuronosyltransferase 2B17 in human liver and intestine and its role in testosterone first-pass metabolism. Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens
2 To further investigate the quantitative role of UGT2B17 in testosterone metabolism in whole cell system, a targeted metabolomics study was performed in hepatocytes (n = 5) and enterocytes (n = 16). Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens
3 These observational and mechanistic data will be useful in developing physiologically-based pharmacokinetic (PBPK) models for predicting highly-variable first-pass metabolism of testosterone and other UGT2B17 substrates. Testosterone UDP glucuronosyltransferase family 2 member B17 Homo sapiens