Pub. Date : 2018 Oct
PMID : 30086088
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women-A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients. | Lamotrigine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 2 | BACKGROUND: Previous studies have reported inconsistent findings regarding the impact of the UGT1A4*3 variant allele on lamotrigine (LTG) exposure. | Lamotrigine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 3 | BACKGROUND: Previous studies have reported inconsistent findings regarding the impact of the UGT1A4*3 variant allele on lamotrigine (LTG) exposure. | Lamotrigine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 4 | As no studies have controlled for nongenetic factors, the aim of this study was to compare serum concentrations of LTG in carriers versus noncarriers of UGT1A4*3 adjusting for differences in age, sex, and valproic acid (VPA) comedication. | Lamotrigine | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |