Title : Germline single nucleotide polymorphisms in ERBB3 and BARD1 genes result in a worse relapse free survival response for HER2-positive breast cancer patients treated with adjuvant based docetaxel, carboplatin and trastuzumab (TCH).

Pub. Date : 2018

PMID : 30071039






3 Functional Relationships(s)
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1 Germline single nucleotide polymorphisms in ERBB3 and BARD1 genes result in a worse relapse free survival response for HER2-positive breast cancer patients treated with adjuvant based docetaxel, carboplatin and trastuzumab (TCH). thiocarbohydrazide BRCA1 associated RING domain 1 Homo sapiens
2 We found that patients on a TCH based regimen with the minor allele of the ERBB3 (rs2229046 and rs773123) and BARD1 (rs2070096) SNPs, were significantly more likely to relapse than those women who were not. thiocarbohydrazide BRCA1 associated RING domain 1 Homo sapiens
3 The BARD1 and ERBB3 SNPs can potentially be used to determine those patients that will have a worse response to TCH based treatment, an effect that may arise from the SNPs impact on altered cellular signaling. thiocarbohydrazide BRCA1 associated RING domain 1 Homo sapiens