Title : Increased β2-adrenoceptor phosphorylation in airway smooth muscle in severe asthma: possible role of mast cell-derived growth factors.

Pub. Date : 2018 Nov

PMID : 30069878






1 Functional Relationships(s)
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1 This blunted beta2 -AR response was reproduced by treating ASM cells with TGF-beta1 or fibroblast growth factor (FGF)-2, which induced beta2 -AR phosphorylation at tyrosine residues Tyr141 and Tyr350 , and significantly reduced the maximal bronchorelaxant responses to isoproterenol in human precision cut lung slices (PCLS). Tyrosine transforming growth factor beta 1 Homo sapiens