Pub. Date : 2019 Mar
PMID : 30066962
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further research revealed that both protein phosphatase 2A (PP2A) and phosphatase and tensin homolog (PTEN)-Akt were implicated in resveratrol-inactivated Erk1/2-dependent cell adhesion. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Overexpression of wild-type PTEN or dominant-negative Akt or inhibition of Akt with Akt inhibitor X strengthened resveratrol"s inhibition of the basal or IGF-1-stimulated Erk1/2 phosphorylation and cell adhesion. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Overexpression of wild-type PTEN or dominant-negative Akt or inhibition of Akt with Akt inhibitor X strengthened resveratrol"s inhibition of the basal or IGF-1-stimulated Erk1/2 phosphorylation and cell adhesion. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Overexpression of wild-type PTEN or dominant-negative Akt or inhibition of Akt with Akt inhibitor X strengthened resveratrol"s inhibition of the basal or IGF-1-stimulated Erk1/2 phosphorylation and cell adhesion. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Furthermore, inhibition of mechanistic/mammalian target of rapamycin (mTOR) with rapamycin or silencing mTOR enhanced resveratrol"s inhibitory effects on the basal and IGF-1-induced inhibition of PP2A-PTEN, activation of Akt-Erk1/2, and cell adhesion. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |