Title : HSP90 limits thrombin‑stimulated IL‑6 synthesis in osteoblast‑like MC3T3‑E1 cells: Regulation of p38 MAPK.

Pub. Date : 2018 Oct

PMID : 30066835






2 Functional Relationships(s)
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1 17-AAG and geldanamycin markedly potentiated the thrombin-induced phosphorylation of p38 MAPK without affecting the phosphorylation of p44/p42 MAPK or myosin phosphatase targeting subunit, a substrate of Rho-kinase. tanespimycin mitogen-activated protein kinase 14 Mus musculus
2 Additionally, the enhancement by 17-AAG of the thrombin-stimulated release of IL-6 was significantly reduced by SB203580, an inhibitor of p38 MAPK. tanespimycin mitogen-activated protein kinase 14 Mus musculus