Pub. Date : 2018 Oct
PMID : 30065099
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because the PI3K/AKT/mTOR pathway is one of the major downstream pathways of EGFR, we hypothesized that ibrutinib"s activity might be enhanced by combination therapy with auranofin in NSCLC cells. | ibrutinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The combination of ibrutinib and auranofin led to a dramatically enhanced inhibition of the expression or phosphorylation of multiple key nodes in the AKT/mTOR and MEK/ERK pathways in both cell lines. | ibrutinib | AKT serine/threonine kinase 1 | Homo sapiens |