Title : In vitro changes in the proportion of protein-unbound-free propofol induced by valproate.

Pub. Date : 2018 Oct

PMID : 30062394






4 Functional Relationships(s)
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1 RESULTS: In the serum samples with normal albumin concentrations, 1 mg/mL VPA significantly increased the proportion of protein-unbound-free propofol at 1 and 5 microg/mL propofol. Propofol thrombopoietin Mus musculus
2 RESULTS: In the serum samples with normal albumin concentrations, 1 mg/mL VPA significantly increased the proportion of protein-unbound-free propofol at 1 and 5 microg/mL propofol. Propofol thrombopoietin Mus musculus
3 Furthermore, in the serum samples with low albumin concentrations, the proportion of protein-unbound-free propofol was significantly increased by both 0.1 and 1 mg/mL VPA at propofol concentrations of 1 and 5 microg/mL. Propofol thrombopoietin Mus musculus
4 Furthermore, in the serum samples with low albumin concentrations, the proportion of protein-unbound-free propofol was significantly increased by both 0.1 and 1 mg/mL VPA at propofol concentrations of 1 and 5 microg/mL. Propofol thrombopoietin Mus musculus