Title : Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control.

Pub. Date : 2018 Dec

PMID : 30054897






5 Functional Relationships(s)
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1 Nicotine"s weight effects appear to result especially from the drug"s stimulation of alpha3beta4 nicotine acetylcholine receptors (nAChRs), which are located on pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), leading to activation of the melanocortin circuit, which is associated with body weight. Nicotine proopiomelanocortin Homo sapiens
2 Nicotine"s weight effects appear to result especially from the drug"s stimulation of alpha3beta4 nicotine acetylcholine receptors (nAChRs), which are located on pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), leading to activation of the melanocortin circuit, which is associated with body weight. Nicotine proopiomelanocortin Homo sapiens
3 Nicotine"s weight effects appear to result especially from the drug"s stimulation of alpha3beta4 nicotine acetylcholine receptors (nAChRs), which are located on pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), leading to activation of the melanocortin circuit, which is associated with body weight. Nicotine proopiomelanocortin Homo sapiens
4 Nicotine"s weight effects appear to result especially from the drug"s stimulation of alpha3beta4 nicotine acetylcholine receptors (nAChRs), which are located on pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC), leading to activation of the melanocortin circuit, which is associated with body weight. Nicotine proopiomelanocortin Homo sapiens
5 This review summarizes current understanding of the regulatory effects of nicotine on food intake and body weight according to the findings from pharmacological, molecular genetic, electrophysiological, and feeding studies on these appetite-regulating molecules, such as alpha3beta4, alpha7, and alpha4beta2 nAChRs; neuropeptide Y (NPY); POMC; melanocortin 4 receptor (MC4R); agouti-related peptide (AgRP); leptin, ghrelin, and protein YY (PYY). Nicotine proopiomelanocortin Homo sapiens