Title : Human chorionic gonadotropin stimulation of estradiol production and androgen antagonism of gonadotropin-stimulated responses in cultured human granulosa-luteal cells.

Pub. Date : 1986 Apr

PMID : 3005352






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 hCG (0.01-10 IU/ml) stimulated a 3- to 13-fold increase in progesterone production. Progesterone hypertrichosis 2 (generalised, congenital) Homo sapiens
2 However, at hCG concentrations greater than 1 IU/ml, coincubation with testosterone (10(-7) M) significantly inhibited progesterone production. Progesterone hypertrichosis 2 (generalised, congenital) Homo sapiens
3 In addition, the presence of testosterone (10(-7) M) antagonizes hCG-stimulated progesterone and LH receptor production by these cells. Progesterone hypertrichosis 2 (generalised, congenital) Homo sapiens