Title : G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions.

Pub. Date : 2018 Sep 5

PMID : 30053407






3 Functional Relationships(s)
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1 Gpr39 expression increased in thioglycollate-induced peritoneal macrophages. Thioglycolates G protein-coupled receptor 39 Mus musculus
2 TC-G 1008, a G protein-coupled receptor 39 agonist, enhanced interleukin (IL)-10 production from thioglycollate-induced peritoneal macrophages stimulated with lipopolysaccharide (LPS) in vitro. Thioglycolates G protein-coupled receptor 39 Mus musculus
3 The ablation of G protein-coupled receptor 39 significantly reduced IL-10 production by TC-G 1008 in thioglycollate-induced peritoneal macrophages stimulated with LPS and in the LPS-induced murine model of sepsis. Thioglycolates G protein-coupled receptor 39 Mus musculus