Title : Metabolome-guided genomics to identify pathogenic variants in isocitrate dehydrogenase, fumarate hydratase, and succinate dehydrogenase genes in pheochromocytoma and paraganglioma.

Pub. Date : 2019 Mar

PMID : 30050099






1 Functional Relationships(s)
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1 PURPOSE: Metabolic aberrations have been described in neoplasms with pathogenic variants (PV) in the Krebs cycle genes encoding succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH). krebs isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens