Title : Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats.

Pub. Date : 2018 Jul 24

PMID : 30041644






2 Functional Relationships(s)
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1 In the present study, we studied the expression of Foxo1, Gsk3beta and PI3K-Akt-mTOR in the brain of streptozotocin-induced type 2 diabetes mellitus Wistar rats. Streptozocin forkhead box O1 Rattus norvegicus
2 Brain tissue of STZ-induced type 2 DM animals showed a significant reduction in secondary messengers of insulin signalling (Foxo1) (P < 0.001) and Gsk3beta (P < 0.01) and a significant alteration in the expression of phosphorylated-Akt (P < 0.001) mTOR (P < 0.01) and PI3K. Streptozocin forkhead box O1 Rattus norvegicus