Pub. Date : 2018 Oct 15
PMID : 30036686
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, nicotine (0.1-10 muM) reduced the expression of LXRalpha, LXRbeta, SR-B1, ABCA1 and ABCG1 in a concentration dependent manner, which could be annulled by nAChR antagonist and LXR agonist. | Nicotine | ATP binding cassette subfamily G member 1 | Rattus norvegicus |
| 2 | Taken together, nicotine could inhibit the expression of SR-B1, ABCA1 and ABCG1 via nAChR and LXR alpha/beta in female placentas, finally leading to reduced blood cholesterol levels in fetal rats. | Nicotine | ATP binding cassette subfamily G member 1 | Rattus norvegicus |