Title : Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics.

Pub. Date : 2018 Jun 29

PMID : 30034619






2 Functional Relationships(s)
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1 Here, we show that attenuation of HMGCR expression in the presence of atorvastatin leads to stronger growth inhibition than dual target blockade of the mevalonate pathway in relatively statin resistant cell lines, mainly through inhibition of protein prenylation pathways. Atorvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens
2 Thus, combined inhibition of the mevalonate pathway"s rate-limiting enzyme, HMGCR, can improve atorvastatin"s growth inhibitory effect on epithelial- and mixed mesenchymal-epithelial cancer cells, a finding that may have implications for the design of future anti-metastatic cancer therapies. Atorvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens