Title : Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics.

Pub. Date : 2018 Jun 29

PMID : 30034619






1 Functional Relationships(s)
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1 Thus, combined inhibition of the mevalonate pathway"s rate-limiting enzyme, HMGCR, can improve atorvastatin"s growth inhibitory effect on epithelial- and mixed mesenchymal-epithelial cancer cells, a finding that may have implications for the design of future anti-metastatic cancer therapies. Mevalonic Acid 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens