Title : Schisanhenol improves learning and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1α-Tau signaling pathway.

Pub. Date : 2019 Feb

PMID : 30033800






3 Functional Relationships(s)
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1 Schisanhenol improves learning and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1alpha-Tau signaling pathway. schisanhenol sirtuin 1 Mus musculus
2 Furthermore, western blotting analysis revealed that Schisanhenol increased the levels of SIRT1 and PGC-1alpha and decreased the level of phosphorylated Tau protein (Ser 396) significantly in the hippocampal tissues. schisanhenol sirtuin 1 Mus musculus
3 CONCLUSIONS: Our findings indicated that Schisanhenol can attenuate scopolamine-induced learning impairment and enhance cognitive function, the mechanism via improve the cholinergic system and antioxidant ability, activate SIRT1-PGC1alpha signaling, inhibit the phosphorylation of Tau, and would be an effective candidate against cognitive disorders, such as Alzheimer"s disease. schisanhenol sirtuin 1 Mus musculus