Title : ROS‑mediated autophagy through the AMPK signaling pathway protects INS‑1 cells from human islet amyloid polypeptide‑induced cytotoxicity.

Pub. Date : 2018 Sep

PMID : 30015901






1 Functional Relationships(s)
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1 Upregulation of autophagy by AMPK activator 5-aminoimidazole-4-carboxamide1-beta-D-ribofuranoside decreased ROS and malondialdehyde generation, whereas inhibition of autophagy by 3-methyladenine and AMPK inhibitor compound C aggravated hIAPP-induced oxidative stress and toxicity in INS-1 cells. 3-methyladenine protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus