Pub. Date : 2018 Oct
PMID : 30015859
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of celastrol on toll-like receptor 4-mediated inflammatory response in free fatty acid-induced HepG2 cells. | celastrol | toll like receptor 4 | Homo sapiens |
| 2 | To directly elucidate whether TLR4 was the blocking target of celastrol upon FFA exposure, the cellular response to inflammation was determined upon transfection with TLR4 siRNA. | celastrol | toll like receptor 4 | Homo sapiens |
| 3 | The results revealed that celastrol significantly reduced triglyceride accumulation in the steatotic HepG2 cells, and downregulated the expression levels of TLR4, MyD88 and phospho-NF-kappaBp65, as well as of the downstream inflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. | celastrol | toll like receptor 4 | Homo sapiens |
| 4 | These results suggest that celastrol exerts its protective effect partly via inhibiting the TLR4-mediated immune and inflammatory response in steatotic HepG2 cells. | celastrol | toll like receptor 4 | Homo sapiens |