Pub. Date : 2018 Sep
PMID : 30009768
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens. | catechol | UDP glucuronosyltransferase family 1 member A8 | Rattus norvegicus |
| 2 | UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens. | catechol | UDP glucuronosyltransferase family 1 member A8 | Rattus norvegicus |
| 3 | Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer. | catechol | UDP glucuronosyltransferase family 1 member A8 | Rattus norvegicus |