Title : β-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells.

Pub. Date : 2018 Aug

PMID : 30008912






4 Functional Relationships(s)
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1 beta-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells. beta-elemene adhesion G protein-coupled receptor A2 Homo sapiens
2 Results demonstrated that beta-elemene-paclitaxel decreased G-protein coupled receptor 124 (GPR124), vascular endothelial growth factor receptor, matrix metallopeptidase (MMP)-3, MMP-9 expression levels and increased endostatin, TIMP metallopeptidase inhibitor (TIMP)-1, TIMP-2 expression in U-2OS cells. beta-elemene adhesion G protein-coupled receptor A2 Homo sapiens
3 Results demonstrated that beta-elemene-paclitaxel decreased G-protein coupled receptor 124 (GPR124), vascular endothelial growth factor receptor, matrix metallopeptidase (MMP)-3, MMP-9 expression levels and increased endostatin, TIMP metallopeptidase inhibitor (TIMP)-1, TIMP-2 expression in U-2OS cells. beta-elemene adhesion G protein-coupled receptor A2 Homo sapiens
4 Immunostaining demonstrated that beta-elemene-paclitaxel treatment increased apoptotic bodies, GPR124 and increased endostatin, TIMP-1 and TIMP-2 expression in tumor tissues. beta-elemene adhesion G protein-coupled receptor A2 Homo sapiens