Title : Vitamin E-stabilized UHMWPE: Biological response on human osteoblasts to wear debris.

Pub. Date : 2018 Nov

PMID : 30006289






2 Functional Relationships(s)
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1 This study investigated in vitro how vitamin E-blended-UHMWPE wear debris might affect osteoblast-mediated osteolysis and the production of RANKL, OPG, Sclerostin and DKK-1, compared to conventional UHMWPE wear debris. Vitamin E sclerostin Homo sapiens
2 Vitamin E doped UHMWPE reduced Sclerostin level, and partially affected DKK-1 production, thereby protecting against bone erosion. Vitamin E sclerostin Homo sapiens