Title : Kinetic analyses and structure-activity relationship studies of synthetic lysine acetylation catalysts.

Pub. Date : 2018 Oct 15

PMID : 30006145






2 Functional Relationships(s)
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1 We previously developed a chemical catalyst, DSH, which activates a chemically stable thioester including acyl-CoA, allowing the site-selective lysine acylation of histones under physiological conditions. Lysine dishevelled segment polarity protein 1 pseudogene 1 Homo sapiens
2 We, herein, conducted a kinetic analysis of the ability of DSH and several derivatives to mediate lysine acetylation to better understand the structural elements essential for high acetylation activity under physiological conditions. Lysine dishevelled segment polarity protein 1 pseudogene 1 Homo sapiens