Title : Microsomal C-25 hydroxylation of [3H]-vitamin D3 by the fetal and neonatal rat liver.

Pub. Date : 1985 Nov

PMID : 2999689






1 Functional Relationships(s)
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1 When the amount of [3H]-25-hydroxyvitamin D3 formed was expressed in relation to the amount of enzyme present in the reaction medium, a constant C-25 hydroxylation capacity in all age groups was observed suggesting that the cytochrome P-450 isoenzyme responsible for the C-25 hydroxylation of vitamin D3 may be constitutionally determined and that its appearance originates during fetal life. Cholecalciferol cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus