Title : Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition.

Pub. Date : 2018 Aug 23

PMID : 29995408






2 Functional Relationships(s)
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1 The development of a specific inhibitor of cytochrome P450 2A6 (CYP2A6), the major nicotine-metabolizing enzyme in humans, which could be prescribed for the cessation of cigarette smoking, has been undertaken. Nicotine cytochrome P450 family 2 subfamily A member 6 Homo sapiens
2 The development of a specific inhibitor of cytochrome P450 2A6 (CYP2A6), the major nicotine-metabolizing enzyme in humans, which could be prescribed for the cessation of cigarette smoking, has been undertaken. Nicotine cytochrome P450 family 2 subfamily A member 6 Homo sapiens