Title : Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis.

Pub. Date : 2018 Sep 6

PMID : 29991557






1 Functional Relationships(s)
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1 Based upon the observation that 1 subunit of succinyl-CoA synthetase (SCS) physically interacts with the first enzyme of heme synthesis (5-aminolevulinate synthase 2, ALAS2) in erythroid cells, it has been posited that succinyl-CoA for ALA synthesis is provided by the adenosine triphosphate-dependent reverse SCS reaction. succinyl-coenzyme A 5'-aminolevulinate synthase 2 Homo sapiens