Title : Hydrogen sulfide inhibits ATP-induced neuroinflammation and Aβ1-42 synthesis by suppressing the activation of STAT3 and cathepsin S.

Pub. Date : 2018 Oct

PMID : 29981830






5 Functional Relationships(s)
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1 Hydrogen sulfide inhibits ATP-induced neuroinflammation and Abeta1-42 synthesis by suppressing the activation of STAT3 and cathepsin S. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus
2 Thereafter, we found that exogenous ATP-induced inflammation and Abeta1-42 production requires the activation of signal transducer and activator of transcription 3 (STAT3) and cathepsin S (Cat S) as inhibition of the activity of either proteins attenuated the effect of exogenous ATP. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus
3 Thereafter, we found that exogenous ATP-induced inflammation and Abeta1-42 production requires the activation of signal transducer and activator of transcription 3 (STAT3) and cathepsin S (Cat S) as inhibition of the activity of either proteins attenuated the effect of exogenous ATP. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus
4 Thereafter, we found that exogenous ATP-induced inflammation and Abeta1-42 production requires the activation of signal transducer and activator of transcription 3 (STAT3) and cathepsin S (Cat S) as inhibition of the activity of either proteins attenuated the effect of exogenous ATP. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus
5 Intriguingly, NaHS suppressed exogenous ATP-induced phosphorylation of STAT3 and the activation of Cat S. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus