Pub. Date : 2018 Aug 15
PMID : 29966607
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salinomycin-induced autophagy blocks apoptosis via the ATG3/AKT/mTOR signaling axis in PC-3 cells. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We further showed that ATG3, a known critical regulator of autophagy, was downregulated and involved in the inhibition of apoptosis by salinomycin-induced autophagy via the AKT/mTOR signaling axis. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | SIGNIFICANCE: Our data indicated that salinomycin-induced autophagy blocks apoptosis via the ATG3/AKT/mTOR signaling axis in PC-3 cells, which provides new clues for the mechanisms of underlying the anti-cancer effects of salinomycin. | salinomycin | AKT serine/threonine kinase 1 | Homo sapiens |