Title : Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation.

Pub. Date : 2018

PMID : 29965988






1 Functional Relationships(s)
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1 Psychostimulants such as cocaine primarily target the central binding site of hDAT and lock the transporter in an outward-facing conformation, thereby inhibiting dopamine reuptake. Cocaine solute carrier family 6 member 3 Homo sapiens