Title : PTEN is indispensable for cells to respond to MAPK inhibitors in myeloid leukemia.

Pub. Date : 2018 Oct

PMID : 29964149






1 Functional Relationships(s)
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1 In this study we demonstrate that a MAPK inhibitor, PD98059, inhibits both AKT and ERK phosphorylation in a human myeloid leukemia cell line (TF-1), but not in PTEN-deficient leukemia cells (TF-1a). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Homo sapiens