Title : Interactions of endocannabinoid virodhamine and related analogs with human monoamine oxidase-A and -B.

Pub. Date : 2018 Sep

PMID : 29958841






2 Functional Relationships(s)
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1 A molecular modeling study of virodhamine with MAO-B and its cofactor flavin adenine dinucleotide (FAD) predicted virodhamine"s terminal -NH2 group to be positioned near the N5 position of FAD, but for docking to MAO-A, virodhamine"s terminal -NH2 group was far away (~6.52 A) from the N5 position of FAD, and encountered bad contacts with nearby water molecules. Flavin-Adenine Dinucleotide monoamine oxidase B Homo sapiens
2 A molecular modeling study of virodhamine with MAO-B and its cofactor flavin adenine dinucleotide (FAD) predicted virodhamine"s terminal -NH2 group to be positioned near the N5 position of FAD, but for docking to MAO-A, virodhamine"s terminal -NH2 group was far away (~6.52 A) from the N5 position of FAD, and encountered bad contacts with nearby water molecules. Flavin-Adenine Dinucleotide monoamine oxidase B Homo sapiens