Title : Bardoxolone Methyl Suppresses Hepatitis B Virus Large Surface Protein Variant W4P-Related Carcinogenesis and Hepatocellular Carcinoma Cell Proliferation Via the Inhibition of Signal Transducer and Activator of Transcription 3 Signaling.

Pub. Date : 2018

PMID : 29953997






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Sublethal concentrations of CDDO-me suppressed STAT3 activation by W4P-LHB ectopic expression and interleukin-6 treatment in W4P-LHB-NIH3T3 and Huh7 cells respectively. bardoxolone methyl signal transducer and activator of transcription 3 Homo sapiens
2 The suppression of STAT3 activation by CDDO-me in W4P-LHB-NIH3T3 cells was further confirmed by decreased cyclin D1 protein levels and increased p21 and p53 mRNA synthesis. bardoxolone methyl signal transducer and activator of transcription 3 Homo sapiens
3 In addition, CDDO-me treatment resulted in decreased cell migration and colony formation in in vitro assays using W4P-LHB-NIH3T3, HepG2, or Huh7 cell lines, supporting its anti-cancer activity through STAT3 inhibition. bardoxolone methyl signal transducer and activator of transcription 3 Homo sapiens
4 Collectively, our findings demonstrated that CDDO-me is capable of suppressing STAT3 activation in HCC cells and cells transformed by the natural variant of HBV protein. bardoxolone methyl signal transducer and activator of transcription 3 Homo sapiens