Title : The differential stimulation of brain and heart cyclic-AMP phosphodiesterase by oncomodulin.

Pub. Date : 1985 Aug 30

PMID : 2994666






1 Functional Relationships(s)
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1 The oncomodulin concentration required for the half-maximal activation of the heart phosphodiesterase was estimated to be 2 X 10(-7)M. In addition, the possibility of the observed activation by oncomodulin being due to calmodulin contamination can be ruled out as the oncomodulin activation profiles were unaltered subsequent to chromatography on organomercurial agarose and the activation by oncomodulin could not be reversed by anti-calmodulin IgG. Sepharose calmodulin Bos taurus