Title : Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.

Pub. Date : 2018 Oct

PMID : 29945920






1 Functional Relationships(s)
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1 Single doses of iberdomide (0.3-6 mg) in healthy volunteers decreased intracellular Aiolos (minimum mean per cent of baseline: 12%-28% (B cells); 0%-33% (T cells)), decreased absolute CD19+ B cells, increased IL-2 and decreased IL-1beta production ex vivo. iberdomide interleukin 1 beta Homo sapiens