Pub. Date : 2016 Apr 8
PMID : 29931961
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Dexmedetomidine prevents inflammatory responses in injured rat lung tissues induced by ischemia/reperfusion through inhibition of TLR4 expression]. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 2 | OBJECTIVE: To investigate the effect of Dexmedetomidine (Dex) on Toll-like receptor 4(TLR4) expression in lung during lung ischemia/reperfusion(I/R) in rats and its possible protecting mechanisms. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 3 | OBJECTIVE: To investigate the effect of Dexmedetomidine (Dex) on Toll-like receptor 4(TLR4) expression in lung during lung ischemia/reperfusion(I/R) in rats and its possible protecting mechanisms. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 4 | (2)Compared with those in the I/R group, W/D and TLW in the Dex group were lower (P<0.05, P<0.01), the mRNA and protein expression levels of TLR4 in lung tissues decreased (P<0.01), and reduced structure damages of lung tissues were observed under light microscopy in Dex group. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 5 | (2)Compared with those in the I/R group, W/D and TLW in the Dex group were lower (P<0.05, P<0.01), the mRNA and protein expression levels of TLR4 in lung tissues decreased (P<0.01), and reduced structure damages of lung tissues were observed under light microscopy in Dex group. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 6 | (3)Compared with those in the Dex group, W/D and TLW in the Dex+Atip group were higher (P<0.01), the mRNA and protein expression levels of TLR4 in lung tissues increased (P<0.01), and the structure damages of lung tissues observed under light microscopy were more serious. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 7 | (3)Compared with those in the Dex group, W/D and TLW in the Dex+Atip group were higher (P<0.01), the mRNA and protein expression levels of TLR4 in lung tissues increased (P<0.01), and the structure damages of lung tissues observed under light microscopy were more serious. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 8 | Dexmedetomidine could inhibit TLR4 expression and alleviate the lung ischemia/reperfusion injury, which was related to activation of alpha2-adreno receptor. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |