Pub. Date : 1985 Jul 31
PMID : 2992490
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of adenosine kinase in the phosphorylation of formycin B in CHO cells. | formycin B | adenosine kinase | Cricetulus griseus |
| 2 | Formycin B-resistant mutants of CHO cells are also affected in AK, as indicated by the absence of AK activity in cell extracts. | formycin B | adenosine kinase | Cricetulus griseus |
| 3 | Formycin B-resistant mutants of CHO cells are also affected in AK, as indicated by the absence of AK activity in cell extracts. | formycin B | adenosine kinase | Cricetulus griseus |
| 4 | Both types of AK- mutants showed reduced uptake and phosphorylation of [3H]formycin B in comparison to the parental (AK+) cells. | formycin B | adenosine kinase | Cricetulus griseus |
| 5 | These observations strongly indicate that in CHO cells, formycin B is phosphorylated via AK and that like other nucleoside analogs its phosphorylation may be essential for the drugs cellular toxicity. | formycin B | adenosine kinase | Cricetulus griseus |