Title : Effects of tebuconazole on cytochrome P450 enzymes, oxidative stress, and endocrine disruption in male rats.

Pub. Date : 2018 Jun 19

PMID : 29923317






3 Functional Relationships(s)
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1 Treatment of rats with tebuconazole decreased glutathione content and increased glutathione S-transferase, superoxide dismutase, catalase, and glutathione peroxidase activities in liver; increased superoxide dismutase activities in kidney and testis; but decreased glutathione S-transferase activity in testis. tebuconazole hematopoietic prostaglandin D synthase Rattus norvegicus
2 Treatment of rats with tebuconazole decreased glutathione content and increased glutathione S-transferase, superoxide dismutase, catalase, and glutathione peroxidase activities in liver; increased superoxide dismutase activities in kidney and testis; but decreased glutathione S-transferase activity in testis. tebuconazole hematopoietic prostaglandin D synthase Rattus norvegicus
3 The present study demonstrates that tebuconazole induces a multiplicity of CYPs and oxidative stress in liver; inhibits testicular P450 and glutathione S-transferase activities; and produces anti-androgenic effects in male rats. tebuconazole hematopoietic prostaglandin D synthase Rattus norvegicus