Title : Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and β1 integrin/FAK-mediated signalling.

Pub. Date : 2018 Sep 5

PMID : 29920241






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Obtained data revealed that ASAH1 was involved in HCT 116 cell response to OXA and that anti-proliferative, pro-apoptotic, anti-migratory and anti-clonogenic effects of OXA could be significantly increased by combination treatment with ASAH1 inhibitor carmofur. carmofur N-acylsphingosine amidohydrolase 1 Homo sapiens
2 Obtained data revealed that ASAH1 was involved in HCT 116 cell response to OXA and that anti-proliferative, pro-apoptotic, anti-migratory and anti-clonogenic effects of OXA could be significantly increased by combination treatment with ASAH1 inhibitor carmofur. carmofur N-acylsphingosine amidohydrolase 1 Homo sapiens