Pub. Date : 2019 Feb
PMID : 29895198
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long non-coding RNA GAS5 sensitizes renal cell carcinoma to sorafenib via miR-21/SOX5 pathway. | Sorafenib | growth arrest specific 5 | Homo sapiens |
| 2 | Herein, we identified that a long noncoding RNA GAS5 was downregulated in sorafenib nonresponsive RCCs. | Sorafenib | growth arrest specific 5 | Homo sapiens |
| 3 | GAS5 overexpression conferred sorafenib sensitive to nonresponsive RCC cells, whereas knockdown of GAS5 promoted responsive RCC cells resistant to sorafenib treatment in vitro and in vivo. | Sorafenib | growth arrest specific 5 | Homo sapiens |
| 4 | GAS5 overexpression conferred sorafenib sensitive to nonresponsive RCC cells, whereas knockdown of GAS5 promoted responsive RCC cells resistant to sorafenib treatment in vitro and in vivo. | Sorafenib | growth arrest specific 5 | Homo sapiens |
| 5 | We proposed that GAS5 was responsible for sorafenib resistance in RCC cells and GAS5 exerted its function through the miR-21/ SOX5 axis. | Sorafenib | growth arrest specific 5 | Homo sapiens |
| 6 | Our findings suggested that GAS5 downregulation may be a new marker of poor response to sorafenib and GAS5 could be a potential therapeutic target for sorafenib treatment in RCC. | Sorafenib | growth arrest specific 5 | Homo sapiens |
| 7 | Our findings suggested that GAS5 downregulation may be a new marker of poor response to sorafenib and GAS5 could be a potential therapeutic target for sorafenib treatment in RCC. | Sorafenib | growth arrest specific 5 | Homo sapiens |